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Yung-Fu Chang Selected Research

Leptospirosis

9/2021Evaluation of new leptospiral antigens for the diagnosis of equine leptospirosis: An approach using pan-genomic analysis, reverse vaccinology and antigenic selection.
1/2019Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design.
5/2017A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4.
1/2017A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis.
2/2016Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira.
1/2016Leptospira Immunoglobulin-Like Protein B (LigB) Binds to Both the C-Terminal 23 Amino Acids of Fibrinogen αC Domain and Factor XIII: Insight into the Mechanism of LigB-Mediated Blockage of Fibrinogen α Chain Cross-Linking.
1/2015Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants.
8/2014NMR solution structure of the terminal immunoglobulin-like domain from the leptospira host-interacting outer membrane protein, LigB.
4/2014Serodiagnosis of equine leptospirosis by enzyme-linked immunosorbent assay using four recombinant protein markers.
1/2014Recombinant antigens rLipL21, rLoa22, rLipL32 and rLigACon4-8 for serological diagnosis of leptospirosis by enzyme-linked immunosorbent assays in dogs.
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Yung-Fu Chang Research Topics

Disease

35Infections
12/2021 - 11/2002
22Leptospirosis
09/2021 - 10/2004
9Paratuberculosis (Johne's Disease)
01/2014 - 02/2008
5Inflammation (Inflammations)
12/2021 - 04/2012
4Neoplasms (Cancer)
01/2022 - 05/2003
3Zoonoses
01/2018 - 01/2009
3Lyme Disease (Disease, Lyme)
09/2017 - 05/2005
3Granuloma
12/2012 - 02/2008
2Hemorrhage
05/2017 - 10/2011
2Diarrhea
03/2015 - 02/2011
2Disease Progression
01/2014 - 12/2012
1Dysbiosis
02/2022
1Immune System Diseases (Immune Disorders)
01/2022
1Jaundice (Icterus)
12/2021
1Dental Fluorosis
07/2021
1Atrophy
01/2021
1Poisoning
01/2021
1Bone Diseases (Bone Disease)
12/2020
1Coma (Comas)
09/2019
1Nocardia Infections
07/2018
1Borrelia Infections
09/2017
1Foot-and-Mouth Disease
01/2017
1Colitis
03/2015
1Body Weight (Weight, Body)
03/2015
1Clostridium Infections
03/2015
1Pneumonia (Pneumonitis)
01/2015
1Reinfection
01/2015
1Bovine Mastitis
10/2014
1Colorectal Neoplasms (Colorectal Cancer)
08/2013
1Tuberculosis (Tuberculoses)
02/2013
1Pseudomembranous Enterocolitis (Pseudomembranous Colitis)
02/2011
1Thrombocytopenia (Thrombopenia)
02/2011
1Thrombosis (Thrombus)
02/2011
1Communicable Diseases (Infectious Diseases)
10/2009

Drug/Important Bio-Agent (IBA)

20VaccinesIBA
01/2019 - 10/2004
18AntigensIBA
09/2021 - 06/2004
17Proteins (Proteins, Gene)FDA Link
12/2021 - 11/2002
8Anti-Bacterial Agents (Antibiotics)IBA
09/2019 - 05/2008
5Subunit VaccinesIBA
07/2018 - 01/2009
4Indicators and Reagents (Reagents)IBA
09/2021 - 06/2004
4EnzymesIBA
04/2014 - 05/2008
4ImmunosorbentsIBA
04/2014 - 05/2008
4AcidsIBA
12/2012 - 02/2008
3Carrier Proteins (Binding Protein)IBA
12/2021 - 06/2008
3Doxycycline (Periostat)FDA LinkGeneric
09/2019 - 05/2005
3Tetracycline (Achromycin)FDA LinkGeneric
09/2017 - 05/2005
3Recombinant ProteinsIBA
03/2015 - 01/2014
3ceftiofurIBA
05/2008 - 01/2003
3Immunoglobulins (Immunoglobulin)IBA
03/2006 - 11/2002
2FluoridesIBA
07/2021 - 01/2021
2Messenger RNA (mRNA)IBA
05/2020 - 03/2004
2CytokinesIBA
05/2017 - 08/2016
2Inactivated VaccinesIBA
09/2015 - 01/2014
2AG 85IBA
02/2013 - 01/2012
2DNA VaccinesIBA
08/2008 - 01/2008
2Staphylococcal Protein A (Protein A)IBA
03/2006 - 11/2002
1Amino AcidsFDA Link
02/2022
1GlycolipidsIBA
02/2022
1CaspasesIBA
01/2022
1butachlor (Machete)IBA
01/2022
1PolyaminesIBA
12/2021
1Scavenger Receptors (Scavenger Receptor)IBA
12/2021
1CopperIBA
10/2021
1FluorineIBA
01/2021
1trichostatin A (A 300)IBA
09/2019
1Protein Subunit VaccinesIBA
07/2018
1beta Lactam AntibioticsIBA
09/2017
1MacrolidesIBA
09/2017
1Immunosuppressive Agents (Immunosuppressants)IBA
05/2017
1Interleukin-6 (Interleukin 6)IBA
05/2017
1Polysaccharides (Glycans)IBA
01/2017
1Immunoglobulin G (IgG)IBA
08/2016
1Immunoglobulin M (IgM)IBA
08/2016
1Metalloproteases (Metalloproteinases)IBA
02/2016
1Hemostatics (Antihemorrhagics)IBA
01/2016
1salicylhydroxamic acid (SHAM)IBA
03/2015
1Gentamicins (Gentamicin)FDA LinkGeneric
10/2014
1Ampicillin (Omnipen)FDA LinkGeneric
10/2014
1Polystyrenes (Polystyrene)IBA
10/2014
1EnrofloxacinIBA
10/2014
1Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric
10/2014
1Synthetic Vaccines (Recombinant Vaccines)IBA
11/2013
1Brefeldin AIBA
08/2013
1TropoelastinIBA
02/2013
1Type III Secretion SystemsIBA
12/2012
1Small Interfering RNA (siRNA)IBA
01/2012
1Membrane Proteins (Integral Membrane Proteins)IBA
10/2011
1Fibronectins (Fibronectin)IBA
11/2009
1Aluminum Hydroxide (Algeldrate)FDA Link
10/2009
1aluminum sulfate (alum)IBA
10/2009
1ElastinIBA
07/2009
1Peptides (Polypeptides)IBA
02/2009
1Liposomes (Liposome)IBA
01/2009

Therapy/Procedure

3Therapeutics
01/2015 - 08/2013
1Intraperitoneal Injections
12/2021
1Chinese Traditional Medicine (Traditional Chinese Medicine)
12/2020
1Oral Administration
09/2019
1Injections
09/2015
1Immunotherapy
01/2015
1Microspheres (Microsphere)
01/2009